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The schematic in Figure 2C captures the sequential progression of hallmark AD features, such as amyloid plaques, tau tangles, neuronal loss, gliosis, synaptic degeneration, and cognitive decline

A key challenge is optimizing the bioavailability and pharmacokinetics of these compounds for oral administration in humans

Additionally, testing for biomarkers such as methylmalonic acid (MMA), may provide valuable insight and help catch B12 deficiency in the earlier stages you can also self-order an MMA lab test via Ulta Lab Tests